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| SFINX interaction database |
| SFINX (Swedish, Finnish, INteraction X-referencing)
is a drug-drug interaction database containing short, concise and
validated information concerning consequences of and recommendations
for more than 12.000 interaction pairs. The database can be integrated
in a medical journal system, or be accessible through the Internet,
and can thus readily facilitate the process of safe drug prescribing
for the individual patient, as the clinician will be guided to choose
the most appropriate action to handle specific drug interactions.
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| Copyright of the database belongs to medbase Ltd in
Turku, Finland, the Karolinska Institute Department of Clinical Pharmacology
in Stockholm, Sweden, and the Division of Drug Management and Informatics
at Stockholm County Council, Sweden. |
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| Content |
| SFINX contains information about relevant pharmacokinetic
interactions that can be supported by scientific literature or by
clinical studies referred to in drug SPCs (Summary of the Product
Characteristics), and furthermore some clinically important pharmacokinetic
interactions, that can be foreseen on the basis of known metabolic
pathways. Documented pharmacodynamic interactions are also included,
unless they are apparent from the main pharmacological action of the
substances, as with e.g. agonists/antagonists to the same receptor. |
| Interaction texts are based on substance names and,
whenever relevant, substance formulations. They are classified according
to clinical significance (A-D) and documentation level (0-4), which
enables threshold settings for automated warnings. All contents of
the database are developed in accordance with documented standard
operating procedures. |
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| Technical solutions |
| Various literature sources are searched for information
concerning drug interactions according to a standard operation procedure
protocol. The information is evaluated and interaction texts are written
in English and divided into five different parts: medical consequence,
recommendation, mechanism, background and references. Medical consequence
and recommendation parts are translated into various languages. All
references are, whenever possible, linked to their source, e.g. PubMed
abstracts. |
| The texts are written by health care professionals
(e.g. physicians or pharmacists) and approved by specialists in clinical
pharmacology. |
| Different terms can be used to connect the database
to the local drug registry: substance name, CAS number, ATC code,
NPLID, registry number of Sweden. A separate list for connection of
drug formulations to the terms used in the database is available. |
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| SFINX is an SQL database, which is updated four times
a year and delivered to our customers as an XML-format export file.
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