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31.1.2025

Clinically significant drug-drug interactions (DDIs) causing adverse drug events are common among older adults (1). A recent study found that these DDIs have a notable impact on the likelihood of hospital admissions related to adverse drug reactions (2).

This risk was particularly high for patients taking medications that increase the risk of bleeding, which doubled the likelihood of ADR-related admissions (2).

Notably, patients experiencing these DDIs also had lower health-related quality of life and extended hospital stays (1,2). These findings underscore the need for careful medication management in older adults.

Drug interactions in older adults can lead to serious adverse events, longer hospital stays, and reduced quality of life.

For comprehensive insights into drug-drug interactions and adverse drug reactions, explore our databases Inxbase and Riskbase.

News produced by Medbase Medical Team

References

1. Hughes JE, Bennett KE, Cahir C. Drug-Drug Interactions and Their Association with Adverse Health Outcomes in the Older Community-Dwelling Population: A Prospective Cohort Study. Clin Drug Investig. 2024 Jun;44(6):439-453. PMID: 38878216
2. Hughes JE, Moriarty F, Bennett KE, Cahir C. Drug-drug interactions and the risk of adverse drug reaction-related hospital admissions in the older population. Br J Clin Pharmacol. 2024 Apr;90(4):959-975. PMID: 37984336