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12.12.2024

Use of systemic tetracycline antibiotics during breastfeeding has long been of concern due to risk of dental staining of the breastfed infant associated with long-term use, such as for treatment of maternal acne. These drugs are excreted into breast milk in relatively low amounts, and, e.g. for doxycycline, it has been shown that simultaneous ingestion of milk reduces the absorption by up to 50% (1).

It appears from literature searches that substantial new information has not been published lately, but the apparent lack of reported adverse effects has led to gradual prolongation of the recommended maximal length of use from one week (2) to the current practice of 3 weeks, as also used by the Helsinki University Hospital Teratology Information Service.

Thus, as a precaution, long term (over 3 weeks) or repeated courses of tetracycline antibiotics seem best to be avoided when breastfeeding, as even low exposure levels over prolonged period of time may lead to adverse effects.

Tetracycline antibiotics can be used for up to three weeks during breast-feeding, as low milk excretion and minimal reported adverse effects have extended the recommended use.

For comprehensive insights into drug safety and efficacy during pregnancy and lactation, explore our databases Gravbase and Lactbase.

News produced by Medbase Medical Team

References

1. Meyer FP, Specht H, Quednow B, Walther H. Influence of milk on the bioavailability of doxycycline–new aspects. Infection. 1989 Jul-Aug;17:245-6.
2. Nahum GG, Uhl K, Kennedy DL. Antibiotic use in pregnancy and lactation: what is and is not known about teratogenic and toxic risks. Obstet Gynecol 2006 May;107(5):1120-38